A grid-based facilities allocation approach with safety and optimal heat exchanger networks synthesis

A new approach is presented to determine optimal layout of facilities where toxic releases may occur in an existing or new facility. The land area is divided in equally sized rectangular grids, where each grid contains up to one facility surrounded by streets. Some facilities may produce hot and/or cold streams and the associated heat exchangers network (HEN) is simultaneously optimized with the layout problem. The three dimensions of geographical allocation points for each generated stream are included in the model. No additional cost for geographical allocation of heating and cooling services is considered since every facility is expected to contain these services regardless of their use in the HEN. The toxic effect is estimated via probit functions and its associated risk reduction results in providing safety to the combined HEN-facility layout problem. The grid-based allocation eliminates numerical difficulties appearing with conventional non-overlapping and Euclidian distance equations.     

Evolution on neutral networks accelerates the ticking rate of the molecular clock

Large sets of genotypes give rise to the same phenotype, because phenotypic expression is highly redundant. Accordingly, a population can accept mutations without altering its phenotype, as long as the genotype mutates into another one on the same set. By linking every pair of genotypes that are mutually accessible through mutation, genotypes organize themselves into neutral networks (NNs). These networks are known to be heterogeneous and assortative, and these properties affect the evolutionary dynamics of the population. By studying the dynamics of populations on NNs with arbitrary topology, we analyse the effect of assortativity, of NN (phenotype) fitness and of network size. We find that the probability that the population leaves the network is smaller the longer the time spent on it. This progressive ‘phenotypic entrapment’ entails a systematic increase in the overdispersion of the process with time and an acceleration in the fixation rate of neutral mutations. We also quantify the variation of these effects with the size of the phenotype and with its fitness relative to that of neighbouring alternatives.     

Maximizing lifetime in wireless sensor networks with multiple sensor families

Wireless sensor networks are generally composed of a large number of hardware devices of the same type, deployed over a region of interest in order to perform a monitoring activity on a set of target points. Nowadays, several different types of sensor devices exist, which are able to monitor different aspects of the region of interest (including sound, vibrations, proximity, chemical contaminants, among others) and may be deployed together in a heterogeneous network. In this work, we face the problem of maximizing the amount of time during which such a network can remain operational, while maintaining at all times a minimum coverage guarantee for all the different sensor types. Some global regularity conditions in order to guarantee a fair level of coverage for each sensor type to each target are also taken into account in a second variant of the proposed problem. For both problem variants we developed an exact approach, which is based on a column generation algorithm whose subproblem is either solved heuristically by means of a genetic algorithm or optimally by an appropriate ILP formulation. In our computational tests the proposed genetic algorithm is shown to be able to dramatically speed up the procedure, enabling the resolution of large-scale instances within reasonable computational times.     

Modeling and analysis of passive worm propagation in the P2P file-sharing network

A number of worms, named P2P (peer-to-peer) passive worms, have recently surfaced, which propagate in P2P file-sharing networks and have posed heavy threats to these networks. In contrast to the majority of Internet worms, it is by exploiting users’ legitimate activities instead of vulnerabilities of networks in which P2P passive worms propagate. This feature evidently slows down their propagation, which results in them not attracting an adequate amount of attention in literature. Meanwhile, this feature visibly increases the difficulty of detecting them, which makes it very possible for them to become epidemic. In this paper, we propose an analytical model for P2P passive worm propagation by adopting epidemiological approaches so as to identify their behaviors and predict the tendency of their propagation accurately. Compared with a few existing models, dynamic characteristics of P2P networks are taken into account. Based on this proposed model, the sufficient condition for the global stability of the worm free equilibrium is derived by applying epidemiological theories. Large scale simulation experiments have validated both the proposed model and the condition.     

Root cause analysis of process fault conditions on an industrial concentrator circuit by use of causality maps and extreme learning machines

Model-based fault diagnosis tends to be too expensive or time-consuming to apply in the mineral processing industries, owing to the complexity and variability of operations. In contrast, data-based methods are inexpensive, but do not exploit the availability of first principle knowledge of plant operations. In this investigation, the use of process causality maps in conjunction with data-based fault diagnosis is considered as a hybrid methodology that can leverage the advantages of both approaches. Extreme learning machine algorithms are used to implement the data-based component of the approach. These algorithms can be deployed rapidly on large-scale systems and have the ability to deal with highly nonlinear systems. Two different variants are considered, viz. one used in combination with principal component analysis, as well as one with a bagging algorithm for fault diagnosis and applied to an industrial concentrator circuit in South Africa. The use of process causality maps led to significantly more effective fault diagnosis, while the use of extreme learning machines in combination with principal component analysis likewise allowed markedly better fault detection and diagnosis. In contrast, fault diagnosis with the bagging approach did not perform particularly well, owing to the high degree of correlation between the variables, which made it difficult to isolate individual causal variables.     

Optimal scheduling of single stage batch plants with direct heat integration

This paper addresses the multi-objective optimization problem arising in the operation of heat integrated batch plants, where makespan and utility consumption are the two conflicting objectives. A new continuous-time MILP formulation with general precedence variables is proposed to simultaneously handle decisions related to timing, product sequencing, heat exchanger matches (selected from a two-stage superstructure) and their heat loads. It features a complex set of timing constraints to synchronize heating and cooling tasks, derived from Generalized Disjunctive Programming. Through the solution of an industrial case study from a vegetable oil refinery, we show that major savings in utilities can be achieved while generating the set of Pareto optimal solutions through the ɛ-constraint method.     

Modelling and predicting the effect of social distancing and travel restrictions on COVID-19 spreading

To date, the only effective means to respond to the spreading of the COVID-19 pandemic are non-pharmaceutical interventions (NPIs), which entail policies to reduce social activity and mobility restrictions. Quantifying their effect is difficult, but it is key to reducing their social and economic consequences. Here, we introduce a meta-population model based on temporal networks, calibrated on the COVID-19 outbreak data in Italy and applied to evaluate the outcomes of these two types of NPIs. Our approach combines the advantages of granular spatial modelling of meta-population models with the ability to realistically describe social contacts via activity-driven networks. We focus on disentangling the impact of these two different types of NPIs: those aiming at reducing individuals’ social activity, for instance through lockdowns, and those that enforce mobility restrictions. We provide a valuable framework to assess the effectiveness of different NPIs, varying with respect to their timing and severity. Results suggest that the effects of mobility restrictions largely depend on the possibility of implementing timely NPIs in the early phases of the outbreak, whereas activity reduction policies should be prioritized afterwards.     

Engineering New Microvascular Networks On-Chip: Ingredients,Assembly, and Best Practices

Tissue engineered grafts show great potential as regenerative implants for diseased or injured tissues within the human body. However, these grafts suffer from poor nutrient perfusion and waste transport, thus decreasing their viability post-transplantation. Graft vascularization is therefore a major area of focus within tissue engineering because biologically relevant conduits for nutrient and oxygen perfusion can improve viability post-implantation. Many researchers used microphysiological systems as testing platforms for potential grafts owing to an ability to integrate vascular networks as well as biological characteristics such as fluid perfusion, 3D architecture, compartmentalization of tissue-specific materials, and biophysical and biochemical cues. Although many methods of vascularizing these systems exist, microvascular self-assembly has great potential for bench-to-clinic translation as it relies on naturally occurring physiological events. In this review, the past decade of literature is highlighted, and the most important and tunable components yielding a self-assembled vascular network on chip are critically discussed: endothelial cell source, tissue-specific supporting cells, biomaterial scaffolds, biochemical cues, and biophysical forces. This paper discusses the bioengineered systems of angiogenesis, vasculogenesis, and lymphangiogenesis and includes a brief overview of multicellular systems. It concludes with future avenues of research to guide the next generation of vascularized microfluidic models.     

Small molecule ternary solar cell with two synergistic electron acceptors for enhanced photovoltaic performance

In recent years, tremendous progresses have been achieved for solution processed organic solar cells (OSCs). The strategy of adding a third component to fabricate ternary solar cells has emerged as an effective method to enhance the power conversion efficiency (PCE) of devices. Furthermore, small molecules feature as lower viscosity and excellent repeatability which facilitate the effective morphology control during fabrication process for enhanced photovoltaic performance. Herein, we report a series of ternary solar cells based on a liquid crystal molecule BTR and two electron acceptors of PC₇₁BM and Y6. These molecules show complementary absorption to broaden spectra coverage and form energy levels cascade for efficient charge transfer. Meanwhile, thanks to the improved molecular packing and formed efficient charge transport network in the ternary blend film, the optimal ternary device possesses the improved charge dynamics and suppressed charge recombination. Thus, ternary solar cells deliver the highest PCE of 11.82% with simultaneously enhanced parameters of J_SC, V_OC and FF. This finding further illustrates the important roles of synergistic effect of fullerenes and non-fullerene acceptors in fabricating highly efficient ternary solar cells.